Free radical scavengers modulate signalling cascades in mdx diaphragm Modulation of p38 MAPK Cascade and Metalloproteinase Activity in Diaphragm Muscle in Response to Free Radical Scavengers administration in Dystrophin-Deficient mdx mice
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چکیده
Abbreviations: DGC, dystrophin glycoprotein complex; DAPC, dystrophin associated protein complex; β-DG, Beta-dystroglycan; ALA, Alpha-lipoic acid; L-Car, L-carnitine; CK, creatine kinase; TBARS, thiobarbituric acid reactions; SOD, superoxide dismutase; CAT, catalase; GPx, glutathione peroxidase; MyHC, myosin heavy chain; HO-1, Heme oxygenase-1; NF-κB, nuclear factor-κB; MMP, Matrix Metalloproteinase; MAPK, Mitogen-activated protein Kinase; ERK, Extracellular signal regulated kinase; JNK, c-Jun N-terminal kinase; Wt, Wild-type; mdx, dystrophin-deficient mice.
منابع مشابه
Modulation of p38 mitogen-activated protein kinase cascade and metalloproteinase activity in diaphragm muscle in response to free radical scavenger administration in dystrophin-deficient Mdx mice.
Duchenne muscular dystrophy muscles undergo increased oxidative stress and altered calcium homeostasis, which contribute to myofiber loss by trigging both necrosis and apoptosis. Here, we asked whether treatment with free radical scavengers could improve the dystrophic pattern of mdx muscles. Five-week-old mdx mice were treated for 2 weeks with alpha-lipoic acid/l-carnitine. This treatment decr...
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